I've got this working now after some more trial and error in DOSBox. It turns out the game was actually objecting to my Windows 3.1 installation. If I rename the windows directory to anything else then it starts up. I suspect it might be expecting to see Win 95 in that directory and getting confused …

I'm struggling to get Cyberia 2 running either on a DOS PC or on DOSBOX. The message I'm getting when I run the game is "The U.K. version of Cyberia2 is not intended to run on U.S. computer systems. Please contact the business where you purchased this product....." Region protection in a DOS game is …