Thanks for replying! After your tip, I've tried vDos and vDosPlus, where vDosPlus was the only program that managed to run my stupid 16bit program, but there was no support for serial connection... So I guess my only option now is to buy a 32bit version of windows 10 to try if ntvdm will work .. …

Hi, I'm using an 16bit program for work, but I'm tired of using the old xp based computer, so trying to get this program to work on windows 10 I stumbled upon dosbox. The happiness was great when the program started just fine, but it didn't last long, as I have to access some filesystem in the same …