I've had 'some' luck with Pandora,
First you need to edit the sound.inf file to turn of sound card verification (add ",1" to the end of each digital soundcard line)
Next edit your config.ini and manually insert the information for a soundblaster 1.0 or pro (sadly only these two 8-bit cards will work).
Use soundblaster FM as your midi as well (although FM does not work this must be set to soundblaster (or adlib essentially) - only the soundblaster drivers work others lock up)
If you are asked to set your soundcard information after this, cancel out.
Now, the built in sound blaster emulation in winXP will work at this point, but not nicely, so I recommend VDMS Launcher.
Oddly enough when usingVDMS make sure it is emulating a SB16 *NOT* a Sb1.0 to match you config file (why? I don't know but it works much better this way), turn OFF midi and adlib support.
Turn on MSCDex, VESA, and DOSX support.
Give it some XMS, but no EMS.
You may also want to cap cpu usage to low, if the movies are choppy.
Now run the game (I recommend running tex4.exe rather than "pandora directive.exe" but either will work)
NOW - the end result of this is that pandora should start, BUT the problem is the interface moves incredibly slow. I can't figure this one out. Movies and sounds play fine for me (Minus MIDI), and VR movement is quick, but the actual Look, Get, ... Interface moves slow. You may consider this playable, you may not.
As a side note, much of this also works with Under a Killing Moon, but it still has some movie and sound troubles.