I don't know specifically how you do it with D-Fend Reloaded, but in standard DOSBox all you have to do is specify the name of each ISO image when you use the imgmount command, and you can subsequently swap CDs by pressing CTRL-F4 when the game prompts you. Details are in the readme.

If you don't want the game to prompt you for CDs at all, well, that will probably require a game-specific hack.

Board index ‹ The Guide ‹ DOS
This should be in DOSBox General

TAKE2.INI contains this:
Drive1 = D:\
Drive2 = D:\
Drive3 = D:\
Drive4 = D:\
Drive5 = D:\
Drive6 = D:\

Example:
If you used the command MOUNT C C:\DOS\GAMES\RIPPER -t dir
Copy the contents of the CDs to C:\DOS\GAMES\RIPPER\RIPPER\CD2, C:\DOS\GAMES\RIPPER\RIPPER\CD3, etc.

Edit TAKE2.INI
Drive1 = D:\
Drive2 = C:\RIPPER\CD2
Drive3 = C:\RIPPER\CD3
Drive4 = C:\RIPPER\CD4
Drive5 = C:\RIPPER\CD5
Drive6 = C:\RIPPER\CD6

If this works you should just need CD1 mounted and the rest will be read from the game directory.

Ok that looks like it may work SKARDAVNELNATE. I've been trying to figure this out on my own for weeks 🤣. But, I have one more question. Do I copy the folders from the CDs onto my HDD or do I just copy the files in each folder to the CD2, CD3 etc. folders?

Examples

CD2 has 4 folders - COMBAT, CYBER, PUZZLE, and SCENE
You would copy these into a folder named CD2 resulting in this
C:\RIPPER\CD2\COMBAT
C:\RIPPER\CD2\CYBER
C:\RIPPER\CD2\PUZZLE
C:\RIPPER\CD2\SCENE

CD3 has 3 folders - COMBAT, PUZZLE, and SCENE
You would copy these into a folder named CD3 resulting in this
C:\RIPPER\CD3\COMBAT
C:\RIPPER\CD3\PUZZLE
C:\RIPPER\CD3\SCENE

Thank you very much I'll give it a go.

[Thread moved to DOSBox General Section]