Edit: Figured out the problem. Doxbox seems to not play nicely with G-Sync. I have a G-Sync monitor and have it enabled. On a whim, I disabled it and the problem was resolved. That said, does anyone know what the underlying issue might be and how to correct it so that I don't have to manually disabled G-Sync every time I want to play a game in Dosbox?

Furthermore, what should my Nvidia control panel settings be for Dosbox? Here's what they look like now:

http://imgur.com/a/Vl48O

I originally noticed this problem while playing Space Quest IV but it has manifested in other games such as King's Quest IV and […]
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I originally noticed this problem while playing Space Quest IV but it has manifested in other games such as King's Quest IV and Quest for Glory II. While playing, if I move the mouse cursor the game and the game's audio will stutter. An example can be seen here:

https://youtu.be/k11fjOJLO1g?t=28

I am running Dosbox 0.74 on the following machine:

Windows 10 64-bit
Titan X Pascal
256 GB SSD
8 GB DDR3 RAM
Razer Deathadder Chroma mouse
Razer Blackwidow Chroma keyboard

Dosbox conf file:

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1# This DOSBox configuration file was automatically created by D-Fend Reloaded.
2# Changes made to this file will NOT be transfered to D-Rend Reloaded profiles list.
3# D-Fend Reloaded will delete this file from temp directory on program close.
4
5# Command line used when starting DOSBox:
6# -CONF "C:\Users\lmill\AppData\Local\Temp\Space Quest IV - Roger Wilco and the Time Rippers.conf" -NOCONSOLE
7
8# Config file for profile "Space Quest IV - Roger Wilco and the Time Rippers"
9
10[sdl]
11fullscreen=true
12fulldouble=false
13fullresolution=1920x1080
14windowresolution=1024x768
15output=overlay
16autolock=true
17sensitivity=100
18waitonerror=true
19usescancodes=true
20priority=higher,normal
21mapperfile=L:\Games\D-Fend Reloaded\mapper.map
22
23[dosbox]
24machine=svga_s3
25captures=L:\Games\D-Fend Reloaded\Capture\Sierra41\
26memsize=16
27
28[render]
29frameskip=0
30aspect=true
31scaler=normal3x
32
33[cpu]
34core=normal
35cputype=auto
36cycles=fixed 10000
37cycleup=10
38cycledown=20
39
40[mixer]
41nosound=false
42rate=44100
43blocksize=1024
44prebuffer=10
45
46[midi]
47mpu401=intelligent
48mididevice=default
49midiconfig=
50
51[sblaster]
52sbtype=sb16
53sbbase=220
54irq=7
55dma=1
56hdma=5
57sbmixer=true
58oplmode=auto
59oplrate=44100
60oplemu=default

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61
62[gus]
63gus=false
64gusrate=44100
65gusbase=240
66gusirq=5
67gusdma=1
68ultradir=C:\ULTRASND
69
70[speaker]
71pcspeaker=true
72pcrate=44100
73tandy=auto
74tandyrate=44100
75disney=true
76
77[dos]
78xms=true
79ems=true
80umb=true
81keyboardlayout=US
82
83[joystick]
84joysticktype=none
85timed=true
86autofire=false
87swap34=false
88buttonwrap=false
89
90[serial]
91serial1=dummy
92serial2=dummy
93serial3=disabled
94serial4=disabled
95
96[autoexec]
97@echo off
98SET PATH=Z:\
99keyb US 437
100mount C "L:\Games\D-FEND~1\VIRTUA~1\"
101echo.
102C:
103cd\
104cd \GAMES\SQ4
105Z:\config.com -securemode > nul
106SIERRA.EXE
107exit