There's no such thing as a best build with savestates.

The entire concept of save states can't apply well with file locking, virtual memory, and how DOSBox is initialized. It's not a console system where you could always emulate with a constant of ROM data and memory (to reliably state it up there).

dosbox-x has support for savestates, and while it has been enhanced recently, it is not perfect. Better test if it works with your game of choice before relying on it.