Well...I don't see any harm in testing it, but you should know there are still issues. Basically when glide is running, the wrapper has control of the dosbox window - that means no switching to fullscreen, fullfixed and such options will not work. Also some wrappers like to change screen resolution or set fullscreen by default. Do not change the port setting in dosbox.conf. It is currently hardcoded to 0x300 in glide2x.ovl so anything other than that will not work! What I am trying to say is that right now there is no support for this. If it works for you, enjoy it, if not wait till it's fixed.
Some games run slow and D3D wrappers (like psvoodoo) have some advantage in running these games faster. Other games just run slow 😀. Tomb Rider is an exception since it really benefits from glide - it runs very smoothly!
@Freddo: I didn't tell you, but RedGuard currently runs very slow in dosbox. But try it out anyway. Be sure to start the game with a low cycle count (about 15.000), then bump the cycles to about 40.000 when the game is loading (& it will still take a few minutes to load). My proc then maxes out at about 20.000 cycles in gameplay...