I quote myself:

Darth Marsden wrote:

One you've made the two .bin files, create a subfolder called 'CD' in your main DW2 directory (In my case, that'd be C:\Discworld\Discworld II\CD\) and place both .bin files in there.

If you're still having trouble...

In C:\Discworld\DW2, you should have the following files:
- AILDRVR.LST
- dosbox.conf
- dosbox.exe
- DOSCONF
- DW2.BAT
- DWB.EXE
- RM.DRV
- SBLASTER.DIG
- sdl.dll
- sdl_net.dll
- SETSOUND.EXE

You should also have a sub-folder, called CD. Inside this sub-folder (C:\Discworld\DW2\CD), you should have the following files:
- Disc1.bin
- Disc2.bin

If the .bin files are anywhere else, the game won't run - you'll be prompted for one of the CDs whenever you start the game.