It works for me in DOSBox 0.74 with default settings. In the sound setup program choose "Soundblaster", "Soundblaster FM", 220, 7, 1 -- any other type of Soundblaster causes the game to crash. You can choose SBPro FM or SB16 FM for music, but I'm not sure if it really makes a difference.

Weird... Still hangs This is my sound configuration in DosBOX...

sbtype=sb16
sbbase=220
irq=7
dma=1
hdma=5
sbmixer=true
oplmode=auto
oplemu=default
oplrate=44100

Also, this is the SNDSETUP.INF file created by Tube sound setup program. Could you please paste yours?

SOUND = SBPRO 220 7 1
MUSIC = SBPRO 388 0 0

Following my instructions should have given you a SNDSETUP.INF with "SBLAST" rather than "SBPRO" in it. Maybe your .INF file is read-only or you have the game in some folder where DOSBox does not have write access.

Nope. I deleted the SNDSETUP.INF and ran the setup with "No sound option". It did not hang the sound setup program, but obviously did not have any sound. Editing it manually, the game ran, but still without sound. 🙁

Why did you delete the INF file? Just select "Soundblaster" in the setup program and it should put "SBLAST" into the INF file -- if that isn't happening then you seem to have some file access issue.

Currently sndsetup.inf...

SOUND = SBLAST 220 7 1
MUSIC = SBPRO 388 0 0

Still no sound... I wonder if I have a buggy version of Tube.

BTW, what's your CPU config in DOSBox? Mine is:

core=normal
cputype=auto
cycles=auto
cycleup=10
cycledown=20