CF cards have IDE/ATA protocol emulation in hardware so one you detect and input the correct C/H/S parameters into BIOS, your PC will just see it as a hard disk. Except it's way lower power and quiet because no moving parts. Other than that though you use the same tools and procedures as with HDD - fdisk, format, system transfer, etc. So in other words, other than CHS values there is no fancy setup of any kind, it just works. And if it doesn't, well, some cards dont, try another one.