Getting the ISA slot on a modern board is all good and well.
However I doubt these industrial boards allow you to disable the internal CPU cache and play with the FSB and Multi settings to slow the machine down.
If they do, well that would be awesome. Can anyone confirm?
Once you use W98 why would you need a ISA sound card? Aren't Windows games simply accessing the card through the windows driver, so a PCI Sound Blaster would do the job (or whatever other PCI cards where popular around that time).
I do like DOSBox a lot, but it's all in the detail. In "Heart of China" when you go into the bar right after the start, the screen scrolls from the right to the left. It's super smooth on a real PC. As if someone takes a Picture and moves it.
On DOSBox it's very jittery. Now you can enable "Double Buffering" which makes the scrolling smooth, but then the sound slows down / stutters...
I slowly come to the conclusion that there is no ideal way. They have their challenges on way or another.