Abuse

and to make things easier here is a video with Abuse gameplay: http://www.youtube.com/watch?v=l8cYYPpRboo
is this the one?

Sry its not Abuse, the gameplay was way slower and the game was more colourfull and wat was very significant were theese number puzzles that you had to solve to open some doors, the looked like
------------------------------------
| 45 65 12 87 01 45 21 88 ?? |
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and you had to solve the last number, just an example for this

Could it be super solvers: outnumbered?

Nope, its not super solvers: outnumbered?
it was not so comic like

math rescue ?
http://www.mobygames.com/game/dos/math-rescue/screenshots

Sadly not, it was no educational game. it looked "seriosly"
Thanks so far for searching and thinking bros 😀

The Search wasn´t succussfull yet, so here some more Informations
Games that are NOT the ones I look for are:
Abuse; super solvers: outnumbered; math rescue; Captain Comic I & II Duke Nukem II; Electro Man; Gateworld; Phylox; Sinaria; Space Quest I; Space Chase; Out of This World; The dig; Wreckers; Starflight; Starquest 21st; Alien Carnage; Math Blaster; Rick Dangerous; Lezac; tryian; Abandoned; Defender; Kernel Exeption; Elite; Flashback; Frontier; Space Station Oblivion; Solar Winds the escape; Rama; Cyborg Hunter; Kult; Black Stone; Zack Mackracken; Turrican; Xain Sleena; Contra; Alien Breed; Supernova; Out there Somewhere; Commander Keen; Another World; Cannon Fodder; Crusader no Remorse: Astrocold; Cybermercs; s.c.a.t.; Space channel; Lightspeed; Dream Warrior;
Here is a Picture of what I remember the game looked like, please keep in mind that my memory of this is 20 years old and I was 6yo back then 😉
http://s1.directupload.net/images/140107/2hmcivcl.jpg

[Thread moved to Milliways Section]

You might want to try the "tip of my joystick" thread on reddit.

Any idea which year you played it first, and if it was released that year or so?

For now, from your original description, I can only imagine EGA-ish (16) colours, but couldn't point it out... any idea if it was EGA or VGA or even CGA?

well i played it first in 1993 i think, i think it had more than 16 colours, maybe vga, but im really not sure

It's a long shot, but could it be Starblade?

(It's an older game, though.)

I doubt this is one of them, but anyway, another Space themed 2D game : Murders in Space.

well the first one looks similiar, but it dosent has a klick ui like the second, i think it just has the game screen with a litte ui in the corners...
but sadly its none of them

I know this is a very old thread but would perhaps the game you're looking for be Phylox?