I noticed something strange in Pandora Tomorrow. It is a small white cross flashing in the dead middle of the screen. I am not sure, but I think it happens more often when I use the mouse. Something Unreal-Engine related, perhaps. I can't show it to you, because it doesn't appear on my ShadowPlay recordings. It also doesn't appear when I use a different d3d8.dll from the Widescreen Patches pack. As for the looks ... it's just two perfect white lines crossed, static, not changing with motion or anything. If you need proof, I'll try and record it with my digital camera.
Try to check App controled fullscreen(DX tab). The other option Disable Alt enter unchecked.
While running the game:
Alt +enter, after fullscreen-window mode madness,if you loose focus
Also uncheck capture mouse in the General tab.
See if this helps.