I have had a lot of trouble running NWN1 while I had an ATi/AMD card. And I think those two options don't work at all on ATi/AMD cards. Better leave them disabled.

To run the game with ATI/AMD card - disable Catalyst A.I. Or rename nwmain.exe to something else then run it. Or delete nwmain.exe profile in atiogl.xml and restart the OS.

I think I played it on HD5670 with no issues... I don't have that card now, but I can try it on HD4870 or mobile 5450. I never had nvidia cards in my main rig and I always played nwn just fine.

edit:

Gamecollector wrote:

To run the game with ATI/AMD card - disable Catalyst A.I. Or rename nwmain.exe to something else then run it. Or delete nwmain.exe profile in atiogl.xml and restart the OS.

That explains it. I almost never install CCC.

Bioware was a NV house at the time and you couldn't blame them considering ATI's OpenGL driver quality back then. I think the game utilizes NV OpenGL extensions. KOTOR had similar quirks (performance, bloom, soft shadows, vertex buffer objects, etc).