Word Munchers Deluxe works on Windows 11. After copying the game data files (*.snd, *.pic, Wmuncher.mms, and Wmuncher.exe) to the hard drive, the game can be played without the CD. I found no issues.
It does use WinG, so you need to have WING32.dll (included on the game CD) in your WINDOWS\SysWOW64 directory.
The Windows 95 version of The Oregon Trail works on Windows 11. From the CD, copy the OTWIN32 directory to the hard drive. You can now play the game without the CD. The only thing that doesn't work is the day-to-night effect (as it uses palette cycling, which only works in 256-color mode). Other than that, I found no issues.
I'll be testing more MECC games down the line.