Unfortunately I lack the skills to compile this myself, It appears to be a 16bit emulation layer for Windows 64. I imagine if this worked, it may resolve some problems with earlier win titles, or at least with the installers. Is anyone able to compile it and share?

https://sourceforge.net/projects/nxvdm/

Edit: there are a couple of threads here discussing 'NTVDM64' but they are not related to this project.