I have a lot of Core2 motherboards ranging from the early C2D chipsets right through to the X48 Rampage Extreme and the EVGA 790i SLI PWM Digital and have found them to all be competent boards (Some better than others, some considerably worse) but if I had to pick one board that has had been stand out for reliability, compatibility and features its a Gigabyte P45t-USB3P board. (CPU support on this board is crazy, supports from the 90nm P4 505 processor right upto the mighty QX9770)
https://www.gigabyte.com/Motherboard/GA-EP45T … USB3P-rev-10#ov <--- Dont let it being DDR3 scare you, its one of the late model boards and DDR3 compatibility is excellent.
This little board is just great and I recommend it highly if you ever come across one, its never missed a beat and is very competent at overclocking should you want to.
I will say the Halo boards are fun to play with but for general use they are overkill, they are also expensive to replace should one up and die, the EVGA 790i PWM board is one such board, replacing that board would be near impossible. I find X38/X48 to be hard to work with if you want to try BIOS modding, Intel for whatever reason decided that these two chipsets cannot work with a large range of Xeon 771 CPUs, any Xeon 771 CPU that supports SMP will never work on these chipsets.