I've come across a couple of problems when trying to run Colonization DOS with VDMsound.

Firstly, no matter what I select as my digitized sound card (SB, SB pro early or late), I simply get static whenever it tries to play a sound effect, instead of the sound. All the settings are configured correctly. Seems that this same problem has also been reported in DOSbox.

Secondly, when a notification comes up in Colonization (you know, a wooden sign with some person above it, notifying you of something), if you don't dismiss the sign for a few seconds, the music starts hanging. Dismiss the notification and it goes back to normal. Very bizarre.