Ah, Spiderman Cartoon Maker. That brings back memories from my first Packard Bell PC's multimedia software bundle. I recall it also included dual sets of MIDI files, one for the FM driver and one for wavetable synthesis sound devices. I know at least mystery.mid includes pitch wheel issues that affect the Windows FM synthesizer, and also affect the OPL3 emulator based synthesizer that's on this forum, because it replicates the same behavior as the old driver. Basically, when the pitch wheel hits the extreme minimum on certain notes, instead of sliding all the way down, it wraps around to fully bent positive.
The same bug affects several MIDI files. One from Doom 2 (Opening To Hell, MAP30; the ocarina right from the start), and several from Duke Nukem 3D (Robocreeping; the instantly sliding string arpeggio slides really wrong here). All sound correct in their respective games' FM drivers, the bug only affects MSOPL.DRV and its derivatives.