Thank you for tips and quick response. After some more research, I landed on MS Virtual PC. Thus far, my little program is installed, and running. Now, I just need to figure out how to print.

No, I am not sure. Suggestion?

OS: Windows Vista, 32-bit DOS-based Software: HYSIM 2.72 (engineering fluid calc stuff) Situation: This program requires recognition of the security device. The security device is a 25-pin serial port plug-in. It is located on COM1, at this moment. I can run DOSBox and execute the software, but …