It's possible to mount 4 CDs and switch between them with ctrl+f4 when you need to swap CDs, I don't know of a method for not swapping at all though...

The real reason isn't having to switch disks for cutscenes as much as the little loading times when the game pauses to load in a sound file from the disk. Since this can happen when you are inspecting items in your inventory or in the 3d world, it can break the rythym of play. It may not sound that drastic, but since it is imperative that you inspect everything, it can be annoying. Thanks again, I'll keep checking back to see if there are any ideas. Not too hopeful, as I think the sound is redbooked to the cd...