To the best of my knowledge - yes.
Enable sound - checked
Sample rate 22050
Block size 2048
Prebuffer 10
Soundblaster:
SB16
Address: 220
IRQ 7
DMA 1
HDMA 5
Opl Mode Auto
Opl rate 22050
Use mixer (checked)
GUS not enabled. (i unchecked this after looking at a site about syndicate but it doesn't seem to have made a difference)
midi intelligent
device default
Enable PC Speaker (checked)
Speaker rate 22050
Tandy Rate 22050
disney sound source enabled.
I am using the D-Fend front end.
Changed syndicate.bat to:
main.exe >nul: /iirq7 /idma1 /iio$220 /c0 as listed in another thread.