Sounds like game is missing some resources. Try copying all necessary files/folders to the HDD and modifying the path statements in the RESOURCE.CFG

I tried copying all files from the CD over to the game's directory, and modified the cfg file to look for files in the game's directory instead of the CD. Same problem still!

Copy the PATCHES folder and the following files to a new folder on your HDD:

65535.MAP, FLYTHRU.SEQ, INSTALL.EXE, INSTALL.HLP, INSTALL.SCR, INSTALL.TXT, README, RESOURCE.000, RESOURCE.AUD, RESOURCE.CFG, RESOURCE.MAP, RESOURCE.SFX, SIERRA.ERR, SIERRA.EXE, VERSION

and all *.DRV files. Edit the RESOURCE.CFG to:

videoDrv = VGA.DRV
soundDrv = GENMIDI.DRV 220
audioDrv = DACBLAST.DRV 220
joyDrv = NO
directory = \SIERRA\QG4CD
cmd = QG4CD
mouseDrv = NONE
memoryDrv = NONE
minMemory = 1600k
brightness= 0
language = 1
minCPU = 386
CD = NO
resAUD = .\
resSFX = .\
patchDir = .\;.\patches
audiosize = 63k

Don't apply any patches except for the NewRisingSun QfG4CD patch. Most of the official Sierra QfG4 patches are for the floppy version only. Start the game with SIERRA.EXE in DOSBox. If you still have problems, you might have a corrupt file.

Should the "directory = " line reflect this new folder? Is this new folder meant to be a clean installation of the game, without actually running the installer?

I tried all that and even started a new game instead of restoring one but the game is still crashing when I try to enter Erana's Garden. 🙁

Any chance that you could send me some of your resource or script files to see if it's really a corrupt file that's causing the crash? I own the original game on CD (though how I could prove that I'm not sure)