I just realized dedicated MIDI cards were also a thing, like that Roland card that uses 8-bit ISA. You hook them up to your regular soundcard. Now that I think about it, Descent did have the option of selecting a dedicated music card, for example. So while it may feel like a 386-era thing, it'd certainly be right at home in a 486 build, especially since EISA is backwards compatible.
I'd probably go for a mix of SCSI and IDE. SCSI could be for a large (for the time) HDD and 250 MB ZIP drive (I feel a great option for data exchange in lieu of USB), while IDE would handle the CD-RW. And maybe another HDD, that one could be for the DOS/Windows partition for instance.
I hear the optimal number of VLB cards one can use before compatibility issues start cropping up would be 2, so I'd definitely go for a video card and an IDE controller card there. EISA would be the SCSI controller, network card and I/O card (if I can find one) , which leaves 3 more cards - one could be an ISA soundcard (maybe AWE32 or something else nice), and the aforementioned Roland midi card. That would just leave us with one more expansion slot to fill, I wonder what card could be used for that. If there were EISA-based USB implementations, that would be ideal, but oh well haha
EDIT: Oh, if all else fails I could also get separate I/O and IDE/Floppy controller cards. I know the multi-cards take care of both functions at the same time and save expansion slots, but I'd kinda like to do the opposite thing here after all.. although I do realize I'd be missing out on the improved speed EISA affords, since I doubt there are non-multi options from the EISA period. More and more functions were becoming integrated, only to make it to the mainboards in the ATX era not long afterwards.