Reply 20 of 25, by sulix
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I'm not sure if any commercial titles used it, but libraries like DS4QB ran the sound system from windows, while the game was a 16-bit QuickBasic executable. Apparently they used some windows-specific clipboard interrupts to send commands back and forth.
The games I remembered usually also provided a "NOSOUND.EXE" or similar for those running in pure DOS, so that at least you could play without windows, even if there was no sound.