Nope, not for the FTP portion, that's the whole point.
File extension restrictions still apply, as per the OP. The FTP server won't stop you uploading anything, but you'll be prevented from adding files to the database if the files don't have a permitted extension.
Use discretion too, don't do silly stuff like upload a 2GB ZIP file that's just full of smaller ZIP files. If you have a big archive full of various drivers, consider splitting it up so the individual drivers appear on the site. It will help when I get the keyword search up and running.
Elianda's given me some suggestions for improving the upload experience, which I'll have a stab at implementing later today.