1. DOS 6.22 supports multiple boot configuration (MultiConfig) blocks in the config.sys file.
2. More conventional memory can be squeezed out in DOS 6.22 compared to DOS 5.0, iirc.
3. DOS 6.22 Supplementation Disk is available to bring back the omitted DOSSHELL.
4. Comes with DEFRAG and SCANDISK.
5. DOS 6.22 comes with newer versions of all essential programs - himem.sys, emm386.exe, smartdrv.exe, etc.
6. Process autoexec.bat and config.sys during boot for step-processing each command, after pressing F8.
7. Other minor enhancements of how certain programs and commands function like certain features in COPY, XCOPY, ouput formatting of certain internal commands like MEM, DIR ,etc.
8. MEMMAKER for better memory management. I still use it. It's pretty good (with it's drawbacks).
(And I also still manually optimize TSRs and control what loads where in the conventional and UMB blocks if needed in certain builds.)
I don't use either the doublespace or drvspace.
The thing is that MS-DOS 5.0 was a HUGE leap over the previous versions and revolutionized many aspects.
But DOS 6, especially DOS 6.22 polished it well.
It is basically an improved DOS 5.0 in all aspects, and there is no need to revert back to 5. (Unless of course DOS 6.22 is not available.)