Just to give a bit more info, CTMMSYS.SYS is Creative's own driver, intended to simplify the programming of the card. 99.9% of games don't use it, and talk to the hardware directly. If you don't load this driver, you won't be able to use Creative's own PLAY.EXE utility to play digitised audio (.wav and .voc files) but beyond that you won't lose anything. I think I have seen one or two games out there that make use of this driver, but I can't remember what they were - all I can remember is they weren't very good. So you won't miss out on much by leaving out this driver.
I haven't seen VIBRA16.SYS before, but looking at it in a hex editor, it provides a CTSOUND driver interface. My old Sound Blaster 2 had a CTSB2.SYS which also provided a CTSOUND interface, and this was used by the CTMMSYS.SYS driver, so I'm guessing CTMMSYS.SYS is a device-independent driver, and the other .SYS files provide the hardware-specific code that CTMMSYS then makes use of. So again, you only lose the ability to run some of Creative's own programs if you leave out these drivers. You also get an error if you try to use a program that requires these drivers, so you'll know if you ever run something that needs them.
I'm not sure whether this is a PnP card, as opposed to a software-configurable card. Given that you aren't running any PnP config managers, it is probably software-configurable. This means most of the settings (apart from the base I/O address) are set by running DIAGNOSE/S. To control the settings used, you put the IRQ/DMA/etc. you want in the BLASTER environment variable then run DIAGNOSE/S which applies those settings to the hardware. Only the base I/O address cannot be set this way, and is controlled via the IOSEL jumpers on the card.
You could try changing the MPU401 address from 330 to 300 in the BLASTER variable then rerunning DIAGNOSE/S to see if that works. Have a look at the BLASTER variable after you have run DIAGNOSE/S (run "SET") to make sure it hasn't changed - apparently DIAGNOSE/S may change it to reflect the hardware (in the case of PnP devices, DIAGNOSE/S does not change any settings and merely updates BLASTER to match the current state of the card, as configured by the PnP manager.)