Well this isn't an exodos support site since we don't support so called "abandonware" here but:
You'd need:
A LBA48 controller that can use hard drives beyond 137GB. IIRC exodos is 500GB compressed.
Windows 95B or any DOS that supports FAT32 and LFN
FAT32 if for some reason you want the entire collection on the hard drive on one partition instead of copying off the network
LFN since the .zips are named with LFN and there are LFN files within each zip (You wouldn't need those but unknown how a non LFN zip utility would handle those).You could of course rename the zips as long as you are tracking what the name of the game is if you didn't want to use LFN.
FAT32 has a max file size of 4GB so that would prevent copying those zips.
Some games are in bin/cue ,iso , clonecd and possibly other formats.
Some games need to be reinstalled to work properly if used on a different system.
Depending on the speed of the system decompressing the zips may take awhile.
It's likely that the games were configured on the assumption that DOSBox was used and so depending on your hardware setup you may need to reconfigure the game.
There is some redundancy of MT-32 ROMS spread around in games so that will eat up space when it shouldn't.
There is duplication of game data for scummvm that will take up additional space.
There are modifcations made to games which may increase the system requirements of the games.
I'm assuming the games have already been cracked so you may encounter issues there.
It's possible if you uncompressed everything that you could run into a filesystem max files issue but I doubt it. At the very least fragmentation would be a concern.
Thinking 32KB cluster size so not sure how much wasted space that would be.
There may be issues with using scandisk on such a large partition
The above does not mention all of the other issues when running DOS games on real hardware and OS.