I tried the latest official dev build but didn't work, worth noting is I have a patched version, more recent than the HOTU one, but I had probs with the HOTU one too.
Exactly what it does is.
There're several different exes the game uses when switching between different things, whenever DosBOX tries to access one of these exes other than the main one, it crashes, it seems that DosBOX can't access'em at all, not only ingame, but also when I try to install the game using DosBOX, it specifically tells me "Can't read xxx.exe".
To replicate this problem, just get -removed- this, and get the manual off Home Of The Underdogs(It's not cracked so you need to answer copy protection systems)
When you start your first flight in space, click S, to go to the Security screen.
There, press D to access the internal Defense screen, as this switches to another exe, in my DosBOX, this first freezes up DosBOX, then crashes it, I've tried all different cores also, such as simple, normal, full, dynamic, none solved the problem.
If you get it to work, please do tell me what CVS you used.