Not that I know of. Back in the early XP days budget cards with more VRAM tended to have lower quality RAM (worse latency, less OC potential) at least with certain manufacturers, but by the late 2000s that was no longer an issue. As for XP or games themselves, as far as I know, they don't care. They use what they need and that's it.

Demonslayer2103 wrote on 2022-12-31, 11:20:

So I have recently built a windows xp computer from some hardware I had kicking around. I'm triple booting windows 7 (so I can use some of my newer steam games) and windows 10(so I can have a easy way to write floppys and burn cds at slow speeds). I'm currently running a gtx 750ti but it has 4gb of vram. Is that an issue for older games?

Quake 4 has some issues on cards with high VRAM amounts, but it is fixable.

Viper Racing's known to break on excess VRAM too