I'm assuming you mean the .COM font loaders that Fontedit creates. They're not "resident" in the usual sense because they're loaded into EGA/VGA video memory rather than program RAM. So it depends on what real graphics hardware would do when you exit a game (that is, changing back to text mode).

now, I THINK that changing modes (on real EGA/VGA hardware) always reloads the default ROM font for the target mode. Maybe this behavior differed across manfuacturers / chipsets, but if I'm right, then fonts created with Fontedit shouldn't normally persist after exiting a game. Maybe there are actual TSRs that help with this.

The app would have to hook int10 (and probably seek to the last non-rom hook
as some tricky TSRs do) which this one may or may not do (/do correctly).