Run the game setup program?

I've tried that 😒 ...I tried setting it up a few times, selecting different options for the sound card. There are several audio options in the setup menu, most of them "sound blaster" variants. None of the options I have chosen have worked...

You aren't trying to play it directly from the CD, are you?

Try my most excellent 60 seconds guide (shameless self plugging)

I actually made another post yesterday, but apparantly, it didn't actually post. I tried re-installing a few times and ran the "setup" a few more, but I did finally get it to work! Getting the sound to work properly also fixed the mouse issue...not sure why, but whatever. Anyway, thanks for all of your help and suggestions - you guys rock!

Sorry for the necro but I'm having same issue.

Does anybody know the correct settings to use? I've tried loads of combos between main sound and sfx and just get the beeping/no mouse issue.

And have you examined the aforementioned 60 Seconds Guide?

In particular:

Configure sound, configure graphics, ...

A safe bet with configuring sound, is to select General MIDI or SoundBlaster. Don't try stuff like Gravis Ultrasound (GUS) or Adlib. If you are asked about details like IO/IRQ/DMA/High DMA addresses when configuring the game to use SoundBlaster for sound, use IO = 220, IRQ = 7, DMA = 1 (and sometimes High DMA = 5).

ADz wrote:

Sorry for the necro

AFTER NEARLY SEVEN YEARS.

I'm sorry, you have NO excuse. 😠

Star Trek 25th Anniversary, dosbox conf file tweaks SO FAR (a work in progress, I am a noob):

Using (vanilla build) dosbox 0.74, running on Win 7 64-bit on an i3-4010 with intel integrated HD4400 laptop.
Dosbox and the game are installed on C:\oldgames - not the windows programs folder)

[sdl]
fullscreen=true When first launches, fullscreen or not
fulldouble=false
fullresolution=1366x768 Put your screensize here, or 0x0
windowresolution=1366x768 or whatever your screensize is. I don't know
output=ddraw Most win 7 and 8 machines do fine with this. If not, overlay. Don't use surface.
autolock=false Because I prefer the cursor NOT get locked inside the window when it windows; some prefer "true".
...left the rest with the defaults in this section

[dosbox]
...left all as defaults

[render]
frameskip=0 No need to change this from default, most games (but not all)
aspect=true keeps original aspect ratio so picture doesn't distort widthwise
scaler=hq3x To my eyes this one looked best of the various options for this parameter

[cpu]
cycles=fixed 13000 Seemed to run nice this way.
...left all else with defaults

[mixer]
nosound=false
rate=44100
blocksize=1024
prebuffer=20

[midi]
mpu401=intelligent
mididevice=default
midiconfig=

[sblaster]
sbtype=sbpro1 Probably would work with sbpro2 or sb16; this is what sounded good to my ears after all night fooling with settings
sbbase=220
irq=7
dma=1
hdma=5
sbmixer=true
oplmode=auto
oplemu=default
oplrate=44100

[gus]
gus=false
....the rest default

[speaker]
pcspeaker=true
pcrate=44100
...the rest defaults, or tandy & disney off

Everything else left default
No added autoexec lines at bottom.

I am using Launchbox version 3.6 as a front-end because it has a nice user launch GUI (boxart, game info, etc.) after you set up the game's dosbox.conf (I set up a dosbox.conf for each game so I can tweak away)... The player just has to click on the boxart in the GUI, and not use a dos command window. This frontend supports multi-cd dos games, and also allows scummvm games to be hooked in.

PS - This is a keyboard-driven game, which is not my preference (however politically unpopular that may be 😀
Controls are often hard to find for old games!! But I found them.
HERE ARE THE CONTROLS

MOUSE
Left Mouse Button select
Right Mouse Button escape from the current selection

KEYBOARD
F1 Key select
Enter Key select
F2 Key clear selection
Esc Key clear selection

NumPad 7 up and left
NumPad 8 up
NumPad 9 up and right
NumPad 4 left
NumPad 5 center controls
NumPad 6 right
NumPad 1 down and left
NumPad 2 down
NumPad 3 down and right

V Key view toggle between the normal bridge view and the view screen
Tab Key toggles between ship movement, fire mode and
Insert Key roll counterclockwise
Delete Key roll clockwise

< Key reduce main view screen magnification
> Key enlarge main view screen magnification

Ctrl + S Key toggle sound effects on/off
Ctrl + M Key toggle music on/off
Ctrl + Q Key quit game
Ctrl + J Key center joystick
Ctrl + P Key pause game

A Key analysis
S Key toggle shields on/off
W Key toggle weapons on/off
O Key enter/exit orbit
N Key takes you to the main star map
D Key damage control
E Key emergency power
H Key hail activates Uhura's communication icon
T Key get advice from Spock
C Key computer
K Key brings up Kirks options icons

ON THE GROUND
T Key talk
L Key look
G Key get
U Key use
I Key inventory (you must be in get or look mode)