I run XCOM: Terror from the Deep without issue. I have the original CD version and I copied the CD files to the HDD, mounted C as the start up batch file and D as the CD rom (filies I had moved to my HDD) and it works fine. My favourite oldie and am very happy because the windows fix that was about crashes religiously. Had previously mounted D as the game CD in my DVD rom drive with no issues either and run with SB16 emulation at 22khz, 10000 cycles, 0 frame skip and full screen. Game runs smooth for me.
Give me a shout if I can help. I need to track down my CD version of UFO Defence. Its great too, though TFTD was (<*cough*> is) way better.
Cheers.
Dewed up Scope
-------------------
DosBox Assistant - Front end for DosBox - HERE - at bottom of page