2.2V is OK but you need good cooling and dont go higher than 2.2V.
At that voltage the CPU will likely run fine at 6x100 MHz, 5.5x100MHz is guaranteed.
Normally a motherboard that can do 2.2V also can do 2.0V, but the setting isnt always documented. Often you have 4 jumpers, the first jumper adds 0.1V the second 0.2V the third 0.4V and the forth 0.8V, no jumpers at all gets you the minimum voltage of 2.0V. Check if this is how your voltage selection block works.
New PC: i9 12900K @5GHz all cores @1.2v. MSI PRO Z690-A. 32GB DDR4 3600 CL14. 3070Ti.
Old PC: Dual Xeon X5690@4.6GHz, EVGA SR-2, 48GB DDR3R@2000MHz, Intel X25-M. GTX 980ti.
Older PC: K6-3+ 400@600MHz, PC-Chips M577, 256MB SDRAM, AWE64, Voodoo Banshee.