Well being an IBM system designed to succeed the 5170 they are fully 100% IBM compatible both forwards and backwwards so no, unless you have software that relies on quirks from clone boards (I have never seen anything aside form a demo or two that exploited specific hardware quirks) there's nothing that won't run on the PS/2 machines.
I have no idea why but Vogons seems to hate them because they typically (there ARE models of the PS/2 with ISA) used MCA. It's proprietary, but then I guess so is EISA as well. Most things like serial, parallel, VGA/XGA and the hard disk interface are integrated (and for some reason I'm the only guy on the planet who has yet to have a drive or any of my spares die). It's when you want ethernet, better video or even sound (things that the usual office person doesn't need) things get expensive. The only exception is Token Ring cards. It's like IBM shipped every PS/2 with one.
They're business machines. They are not designed for gaming or the home but they make really neat and tidy machines, so the value of the sought after MCA cards like ethernet, SCSI and sound Blasters are often very high unless you know people or you're like me and you've been hoarding cards for the past decade.
Then again, if you own an amiga and you say Microchannel is expensive, you got no right to complain. 🤣
"It's science. I ain't gotta explain sh*t"