I have a V5 5500 in my P3 setup. When I go S775, I lose the ability to use it or the lesser brothers. V2SLI might still work, PCI sockets galore, no IRQ needed.
I can throttle my P3 down to around 386-16. It can emulate early 90s in speed. But from there to 500 MHz is a vast gap it can't cover. I can pick 500 MHz, 750 and 1000. Or I pick like 386-16, 25, 33. That is all I found, without swapping in a P2.
A P3 isn't variable in speed really (at least I found nothing that works well), but it can offer great variability in hardware. So if you are a tinkerer, you have OPTIONS. As I just experienced myself, when you go S775, you don't have options. The is the best card for this and for that. Things seem to have clearcut best solutions. Not with a P3. (unless you have many ISA slots)
With S775 and c2d, CPUs can be had quiet again. But now the fitting GPUs act up. I was amazed by the heat even the 4200ti created. It has a commercial "batman" replacement cooler, but still.
Retro PC warning: The things you own end up owning you.