As the resident anti-3DFX guy, I'm going to say no - at least, on the surface of things.
They cost a lot of money and by the time you're paying so much you may as well have gotten a high-end GeForce 2 or even a 4 Ti which will probably do the same stuff better. If you were hell-bent on running Glide on there, then I have no idea, I don't think anything worth bothering with was Glide-only past the V2 anyway, so you could always stick one of those in for compatibility I guess. Not caring about Glide and having never seen any worthwhile games not support D3D or GL, my answer would be to throw the idea in the trash and stuff a GeForce 4 Ti in because that card will run practically anything 98 is going to throw at it and then some, at least, as far as Direct3D and OpenGL are concerned. You could probably even resort to a GeForce 5 if you wanted DX9 support, though I personally dislike that series.
On the other hand, if you really want one? Screw the cost and go for it. I've done similar, like where I could have used a 486DX4, but no, I wanted a damn Pentium instead and nothing else would do, so I paid the price... Still kind of am, given it's been a whole world of trouble up to now, but it's what I wanted and I love it, I've had my monies worth already in the fun I have trying to make it work properly and I'm almost there. If you think you'll always feel something is missing without the V5 then save up and get one, because if that's the case it's the only way you'll be happy with the machine.