I had a Sound Blaster Vibra16 CT4170 card and was interested to find out of if this would work in a Tandy 1000 TX. The thing about the CT4170 is that it does not use any 16-Bit DMA, making it good candidate for use in an 8-Bit slot. First off Diagnose, CTCU, and CTCM do not work on the TX, so some other utility has to be used to configure the card. You can use a utility called CT4170.exe to initialize the card based on the BLASTER environment variable. My BLASTER environment variable is set as:

BLASTER=A220 I5 D1 H1 P330 T6

You can then run CT4170 to initialize the card followed by MIXERSET /P to set the volume in your AUTOEXEC.BAT file. This will not enable the onboard game port on the card which is good since the TX already has two joystick ports. I also disabled IRQ 5 by turning of DIP Switch 2 on the motherboard, so there would not be any conflict. Every game I have tested has worked fine as well as running the test programs for the Sound Blaster 1.0, Sound Blaster 2.0 and Sound Blaster Pro cards. The only downside is the CT4170 does not have a real OPL3 Yamaha FM chip, but the CQM chip by Creative is not that bad. I have attached a ZIP file containing CT4170.exe.