lolo799 wrote:To use a pair of Saturn controllers to play, which are pretty nice to use.
Or any of the other Saturn controllers shown (in the first row?) on the I/O Data product page. Although in the case of the Virtual On Twin Stick, there also exists a dedicated PC version that's basically two joysticks and a gameport split cable in a housing. IIRC, there also exist PC versions of the Arcade sticks, both by Sega and (much better) Hori.
For systems with the appropriate OS and USB ports, I'd recommend using a USB Sega Saturn adapter.