Patch the EXE, of course.

You have access to a very good DOS debugger - the 'heavy' version of DOSBOX v0.65 - just do the work your self...

dvwjr

On my 486 I went with solution 3 - meanwhile I've got switches for SB IRQ (5/7), GUS base address (220/240), MIDI base adress on SB16 and LAPC-I (300/330), and enabling/disabling my old ISA VGA card (this required some soldering on the VGA, but works very well).
Additionally I have switches to control the bus clock (25/33/40 MHz) and CPU multiplicator (2x/3x).
The switch method requires some time to install (and it helps if you already know on which end to grab a soldering iron 😉), but it will be a nifty thing to have, especially if you try out a lot of different old software.

I thought so too.

If not only nifty there are indeed the possible IRQ and base address complications to think of as well.

I've had success with the Sierra MIDI Port Changer, found at QuestStudios.

I've not figured out why, but GENMIDI.DRV is one of the few drivers that will not respond to an address specification in the RESOURCE.CFG. Soundblaster, Game Blaster, etc, have no problem with doing so (e.g. SNDBLAST.DRV 240).

Thanks!

The following Sierra has necessitates such a program (shame I didn't think of it).

I'll still build the switches though as a final solution.

Great program. Highly recommended!

Seems to be a very smart patcher and it should even work with games the author didn't check or know of himself (still Sierra of course).