1. you can make a batch file for this (write a textfile with the text
set SDL_VIDEODRIVER=windib
dosbox.exe
and save it as start.bat in the dosbox folder. To start Dosbox doubleclick this file)
2. the problem could be caused by your graphics card drivers. Try to update them to the latest version and try again to start Dosbox without the ser command.
Edit: No sound: make sure the obvious things are not wrong, e.g. the volume control in Windows set to mute (it can happen, believe me 😀). Or check your dosbox.conf and the game that should have sound.
Or again a driver problem.