I was planning on Fedora KDE, but Copr doesn't seem to have as much in it as Ubuntu PPAs. That probably isn't a problem for me, but it was enough to make me hesitate. On EndeavourOS (based on Arch), I've only used the AUR for AviSynth+ and plugins, which was a miserable failure (an extreme case of dependency hell). On Ubuntu, I was using PPAs for newer versions of packages than the official repository, which won't be a problem for Fedora.
For AviSynth+, the easy way out would be to try running it in Wine or switch the big Ryzen to Windows. That CPU is a waste as a web browsing machine anyway, but it's also currently located in a room next to the non-climate-controlled garage. I don't like how Windows has background processes that make the CPU hit its power limit (88W, but with the I/O die and motherboard peripherals added on, total system power consumption hits 130W) while Task Manager shows no significant CPU usage (even in the individual core chart).