Almost anything is possible with enough effort (money+time), but you have to consider your target market and whether this could actually come close to paying for all that effort, let alone being profitable.
The target market would be people who:
1. Like DOS games enough to want to play them and be willing to either play a specific set of specially made DOS games that don't need tweaking, or are willing tweak things to make them work... and do it on a proprietary system that doesn't work like the MS-DOS they may have known... and again, where do they get the games, and who will help them sort out problems?
2. Aren't nostalgic\picky\old enough to care about anything other than the games themselves (they don't mind a completely made up modern interface for launching games, and they don't want the system itself to look, sound or feel like what they remember... because the system can at best resemble ONE computer, not all the varieties people had)
3. ARE nostalgic\picky enough to not want to run GoG versions or DOSbox (which does an amazingly good job and solves almost all of the issues you have posed, aside from running real hardware)
5. Will find the experience enough of an improvement over DOSbox to keep the product and review it well enough to make others want it (they have to be able to discern high-quality emulated OPL3 or MT32 music vs the real thing... and then say it's worth several hundred dollars)
So really, who is this for? There may be people who fit most of these, but that number is extremely low. The number that fit all of them will certainly not be high enough to ever pay for the work needed.
Again, the best chance of making this work is getting with GoG and making a system that is built to run their updated\emulated versions of games. Sadly, most people already have access to computers that can do that, so there is very little incentive to buy an expensive console for the same purpose. For a more authentic experience... buying old hardware and then reading this forum is the best chance people have at playing old PC games. And there's no way to turn that into a product.