Oh for sure.
As noted, there's a lot that has to be done before anyone can think about building anything.
This is just the start.
Get the reference design in and get a good feel for how it works.
The next step is deciding what to change. It looks like the main parts still exist in the wild but this reference design is very different to most boards made.
The easier route is to copy the components from an existing board so you can at least use a known working bios.
The superio specified seems to be rare. Can't boot without that. That will have to change to something more common like winbond. Then, which one? Maybe the bastardised via combo I mentioned a few posts ago?
The clockgens were generally ICS in most major brands. Eg the p3b was an ICS9250-08 which supported 133fsb and seems to be one of the best of the era. Availability is another question.
Can't boot without that.
The vrms were weak on this design and mosfets have come a long way.
Those all need redesigning - preferably for the full range of ppro>Tualatin voltages/watts AND ideally from the 12v line instead of 5v due to modern psus.
There are 3 main vrms. Core, vtt(signalling), sdram,
Then there's potentially agp, pci vrms. Isa can cope raw dogging off the psu.
Decisions have to be made on the agp and pci side. Is 3.3v agp and 5v pci too limiting? Does the builder want to support a universal 1.5&3.3 agp slot, and/or 3.3/5v pci?
Tualatins required pin mods to run on early boards. Those have to be checked and designed.
Then how crazy do you want to go with extras?
I personally have basically never used an lpt port. I couldn't care less if it was deleted. Same goes for serial but it might be necessary for debugging.
Improvements were made to both to consolidate 50 components into one IC. Is that available?
I do recognise that ide is practically unavailable, so a sata bridge chip would be ideal.
Which one? Just a regular sata slot or an m.2 sata too? 2 or all 4 ports?
Onboard lan? What's available? What meets compatibility requirements?
Onboard sound? What's available? What meets compatibility requirements?
How about a pcie Bridge option? It's getting hard to find some things for this era.
After all that, you still need to pick a board size, make everything fit, and design the trace layouts.
In many ways, this era was maxing signalling in ways we've bypassed now.
Pci is 32 individual traces running side-by-side and absolutely need to be the same length as best as possible. Each one is going to get interference.
The much, much faster pcie is less demanding because it uses multiple individual serial differential pairs operating as a network trunk. Differential pairs send opposite signals down 2 wires. Any interference applies to both in an opposing way, and can be fixed simply.
Eg if I send +3v and -3v down 2 wires, and interference adds 1v, you get +4v and -2v.
Because you know they're supposed to be identical, you can infer that the interference was +1v, so you can -1v from both and reconstruct the original signal. Pci can't do that.
Isa is practically bulletproof through sheer power and slowness, so pci is basically the slowest bus on the potential board and it's going to be challenging.
Fsb/ram is even harder.
Anyway...
Long, long way to go.