Professional level graphics cards never made a whole lot of sense once OpenGL went mainstream for games in the early 2000s era with feature complete ICDs. There are probably some special exceptions for unsupported extensions and Quadros bragged about using ECC memory, but I never saw any real benefit to these products since around their time.
Quadros since then are more valuable for their high quality components, multiple digital outputs, and support contracts than actual performance over consumer hardware. If there isn't a particular feature you want or need, then there isn't much reason to choose it otherwise.
There were some minor exceptions where NVIDIA tried to differentiate itself with special drivers for major packages like AutoCAD and 3D Studio MAX. It's possible that there were some optimizations to be had there, but the software specific optimizations fell away in favor of more generic "certified" drivers.
It was always really cool to see huge professional cards of the past. It's too bad that they never translated into any value on the gaming side.