I go with a combo of scalers+shaders, but you may need a fairly high natural resolution (2560x1600) to do so.
For instance...
320x200 base resolution title
x2 super2xsai scaler
x4 GS4xHqFilter shader
=2560x1600
With the oddball WSXGA+ resolution you are running, it will be hard to get a good picture. You will almost always be dealing with stretched pixels (i.e. one pixel row occupies 2 scanlines, the next 3), which tends to look odd. That or a single initial line is displayed across 2, which tends to result in a messy, blurry output.
More or less, your screen is x5.25 the standard resolution of most DOS games, and I don't know of a good way to scale up an image to that res. You're best bet may be to go with the x4 GS4xHqFilter shader and deal with black bars on all 4 sides of the image (presuming your display allows for non stretched, centered resolutions).