First post, by Great Hierophant
I am thinking that it is irrelevant for games whether an ISA card supports 16-bit digitized audio. No DOS game would have the space for 16-bit digitized sound unless it came on a CD. A DOS game that supports redbook CD-Audio does not need the help of a sound card to output 16-bit digitized audio. Some of the last DOS games support 16-bit digitized audio (Fallout), but they come with Windows versions that can also support it and a PCI sound card too.
I am not sure this holds true for Win 3.1 games. But I am seriously doubting that you really need a Sound Blaster 16 for games.