I'm thinking shell extension:
Right Click .exe, .com, .bat, etc
Extra option in menu: "Load in DOSBox".
Have it write a DOSBOX.BAT file in the game folder, and MOUNT drive, etc as required, then have the AUTOEXEC section (or equiv code) load the BAT file from the mounted location.
I'd suggest having it default to CYCLES=MAX, and CORE=DYNAMIC, maybe a pop-up window prompting [Dynamic / Fast] or [Normal / More Stable] to toggle the .conf file beforehand.
"It is technically possible to make DOSBox less technical to the end user" - 😁
Then less technical users won't feel so intimidated, nor require any DOS command line knowledge, just the knowledge to find a games executable within the Windows Explorer / File Manager (which a far higher percentage of users can do).
Going out and finding a [separate program] DOSBox loader GUI can be quite a complex step to the average Joe end user. [It really isn't as obvious as we might think it is].
The only 'difficult' issues:
(1) Having the DOSBOX.BAT call another .BAT file and return - and frankly I don't think that counts because it has likely already been solved (CALL anyone ?).
(2) Audio Configuration [That is a topic in itself, but quite possible].
I don't code, nor do I have intricate knowledge of the DOSBox code base, however I understand and appreciate that the above is possible (under Win32) and some people in these forums may have the skills to do it. [Despite being more Linux developer, than Win32 dev].
If DOSBox had a few cool things, like that, that hopefully wouldn't take emulation specialists too long to implement, it would be far more popular.
Imagine cracking 10 million downloads in SorceForge.Net within the next 1 or 2 years. 😎