My experience with USB keyboards on DOS is not great. There seems to be a conflict between the keyboard and the PC speaker. Any time the PC speaker is beeping, the keyboard is ignored. If you play a PC speaker game (e.g. Keen 1), gameplay will be ruined. If a game is playing continuous music via the PC speaker, you're effectively locked out of pressing any keys on the keyboard.
A PS2 connection doesn't have such issues onviously. Thus, I also recommend and external conversion device to convert USB to PS2 instead of using the mobo's USB (dunno if extension cards also suffer from the same issue).
Turbo XT 12MHz, EGA, MFM HDD
Intel 386 DX-33, Speedstar 24X, SB 1.5, 1x CD
Intel 486 DX2-66, CL5428 VLB, SBPro 2, 2x CD
IBM BlueLightning 100MHz, CL5428, SB16, 4x CD
Intel Pentium 90, Matrox Millenium 2, SB16, 4x CD
HP Z400, Xeon 3.46GHz, YMF-744, RTX2060